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Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2015 Dec;32(6):840-3. doi: 10.3760/cma.j.issn.1003-9406.2015.06.020.

[Association of rs13405728 polymorphism of LHR gene with slow ovarian response].

[Article in Chinese]

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Center for Reproductive Medicine, Xuzhou Central Hospital, Xuzhou, Jiangsu 221000, P.R. China.



To assess the association of rs13405728 polymorphism of luteinizing hormone receptor (LHR) gene with slow ovarian response during assisted reproductive technology (ART).


Two hundred and thirty-six women were enrolled and grouped according to their genotypes. The rs13405728 polymorphism was genotyped by DNA sequencing.


No signifiicant difference was found in antral follicle count and anti-Mullerian hormone between the three genotypes (P>0.05). The incidence of slow response in genotype GG was lower than in the other two genotypes (P<0.05). There was no significant difference in the amount of follicle stimulating hormone required, the number of follicles ≥14 mm on human chorionic gonadotrophin day, oocytes, mature oocytes, available embryos, and the clinical pregnancy rate among the three genotypes (P>0.05). There was an independent correlation between slow ovarian response with the genotypes of rs13405728, the initial dose of gonadotropin, and the dose of luteinizing hormone required (P<0.05).


Rs13405728 of the LHR gene may be associated with slow ovarian response in ART. Various mechanisms may be involved in the poor response and slow response.

[Indexed for MEDLINE]

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