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J Nutr. 2016 Feb;146(2):290-7. doi: 10.3945/jn.115.220194. Epub 2015 Dec 9.

Artificially Sweetened Beverage Consumption Is Positively Associated with Newly Diagnosed Diabetes in Normal-Weight but Not in Overweight or Obese Brazilian Adults.

Author information

1
Postgraduate Program in Epidemiology, School of Medicine and Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil;
2
Postgraduate Program in Epidemiology, School of Medicine and Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil; Department of Epidemiology, and bbduncan@ufrgs.br.
3
Department of Biostatistics, University of North Carolina, Chapel Hill, NC;
4
Department of Clinical Medicine, Faculty of Medicine and Center for Clinical and Epidemiological Research, University Hospital, University of São Paulo, São Paulo, Brazil; and.
5
Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.
6
Postgraduate Program in Epidemiology, School of Medicine and Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil; Department of Epidemiology, and.

Abstract

BACKGROUND:

Recent animal studies suggest that artificially sweetened beverage (ASB) consumption increases diabetes risk.

OBJECTIVE:

We examined the relation of ASB intake with newly diagnosed diabetes and measures of glucose homeostasis in a large Brazilian cohort of adults.

METHODS:

We used cross-sectional data from 12,884 participants from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). ASB use was assessed by questionnaire and newly diagnosed diabetes by a 2-h 75-g oral glucose tolerance test and/or glycated hemoglobin. Logistic and linear regression analyses were performed to examine the association of ASB consumption with diabetes and continuous measures of glucose homeostasis, respectively.

RESULTS:

Although ASB consumption was not associated with diabetes in logistic regression analyses after adjustment for body mass index (BMI; in kg/m(2)) overall, the association varied across BMI categories (P-interaction = 0.04). Among those with a BMI <25, we found a 15% increase in the adjusted odds of diabetes for each increase in the frequency of ASB consumption per day (P = 0.001); compared with nonusers, ASB users presented monotonic increases in the adjusted ORs (95% CIs) of diabetes with increased frequency of consumption: 1.03 (0.60, 1.77), 1.43 (0.93, 2.20), 1.62 (1.08, 2.44), and 2.51 (1.40, 4.50) for infrequent, 1-2, 3-4, and >4 times/d, respectively. In linear regression analyses, among normal-weight individuals, greater ASB consumption was also associated with increased fasting glucose concentrations (P = 0.01) and poorer β-cell function (P = 0.009). No such associations were seen for those with BMI ≥25. In fact, in overweight or obese participants, greater ASB consumption was significantly associated with improved indexes of insulin resistance and 2-h postload glucose.

CONCLUSIONS:

Normal-weight, but not excess-weight, individuals with greater ASB consumption presented diabetes more frequently and had higher fasting glucose and poorer β-cell function.

KEYWORDS:

BMI; artificially sweetened beverage consumption; glucose intolerance; type 2 diabetes; β-cell function

PMID:
26661840
DOI:
10.3945/jn.115.220194
[Indexed for MEDLINE]

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