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Swiss Med Wkly. 2015 Dec 10;145:w14245. doi: 10.4414/smw.2015.14245. eCollection 2015.

Trends in incidence of oesophageal and gastric cancer according to morphology and anatomical location, in Switzerland 1982-2011.

Author information

1
National Institute for Cancer Epidemiology and Registration (NICER), Zürich, Switzerland; Institute of Social and Preventive Medicine (ISPM), University of Bern, Switzerland.
2
Kantonsspital St. Gallen, Department Oncology and Haematology, St. Gallen, Switzerland.
3
Ticino Cancer Registry, Institute of Pathology, Locarno, Switzerland.
4
Geneva Cancer Registry, Institute of Global Health, University of Geneva, Switzerland.
5
Cancer Registry St Gallen-Appenzell, Cancer League St. Gallen-Appenzell, St. Gallen, Switzerland.
6
Cancer Registry of Basel-Stadt and Basel-Landschaft, Gesundheitsdepartement des Kantons Basel-Stadt, Bereich Gesundheitsdienste, Abteilung Projekte und Services, Basel, Switzerland.
7
SAKK Coordinating Centre, Bern, Switzerland.
8
National Institute for Cancer Epidemiology and Registration (NICER), Zürich, Switzerland.
9
Institute of Social and Preventive Medicine (ISPM), University of Bern, Switzerland.

Abstract

QUESTION UNDER STUDY/PRINCIPLES:

This study aimed to evaluate trends in the incidence of oesophageal and gastric cancer by anatomical location and histology using nationally representative Swiss data.

METHODS:

We included all oesophageal and gastric cancers recorded in 10 Swiss population-based cancer registries 1982-2011. We calculated age-standardised incidence rates (ASIRs) per 100 000 person-years (PY) (European standard) for both cancer sites stratified by sex, language region (German, French-Italian), morphology and anatomical location. To assess time trends, we estimated annual percentage changes (APCs) with 95% confidence intervals (95% CIs).

RESULTS:

ASIR of oesophageal adenocarcinoma increased in both sexes and language regions (p <0.001). The steepest increase occurred in males of the German-speaking region (APC 6.8%, 95% CI 5.8-7.8) with ASIRs of 0.8 per 100,000 PY in 1982-1987 and 3.9 per 100.000 PY in 2007-2011. Incidence of oesophageal squamous cell carcinoma decreased significantly in males of both language regions by around -1.5% per year. In contrast, a slight but significant increase (APC 1.4%, 95% CI 0.3-2.4]) of oesophageal squamous cell carcinoma was observed in females of the German-speaking region. We observed stable rates for cancer of the gastric cardia. The incidence of noncardia gastric cancer decreased substantially in both sexes and language regions (p <0.001).

CONCLUSION:

In Switzerland, the incidence of oesophageal adenocarcinoma has risen whereas incidence of noncardia gastric cancer has decreased substantially as observed in other developed countries.

PMID:
26661828
DOI:
10.4414/smw.2015.14245
[Indexed for MEDLINE]
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