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J Cereb Blood Flow Metab. 2016 Dec;36(12):2211-2222. Epub 2015 Nov 4.

Sensory-parietal cortical stimulation improves motor recovery in severe capsular infarct.

Author information

1
Department of Medical System Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea.
2
Translational Neuroimaging Laboratory, McGill Center for Studies in Aging, Douglas Mental Health University Institute, Montreal, Canada.
3
Department of Pathology, Chonnam National University Medical School, Gwangju, Republic of Korea.
4
Department of Medical System Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea hyoungihl@gist.ac.kr.
5
Departement of Neurosurgery, Presbyterian Medical Center, Jeonju, Republic of Korea.

Abstract

The prevalence of subcortical white matter strokes in elderly patients is on the rise, but these patients show mixed responses to conventional rehabilitative interventions. To examine whether cortical electrical stimulation can promote motor recovery after white matter stroke, we delivered stimulation to a small or wide region of sensory-parietal cortex for two weeks in a rodent model of circumscribed subcortical capsular infarct. The sham-operated group (SOG) showed persistent and severe motor impairments together with decreased activation in bilateral sensorimotor cortices and striatum. In contrast, sensory-parietal cortex stimulation significantly improved motor recovery: final recovery levels were 72.9% of prelesion levels in the wide stimulation group (WSG) and 37% of prelesion levels in the small stimulation group (SSG). The microPET imaging showed reversal of cortical diaschisis in both groups: in both hemispheres for the WSG, and in the hemisphere ipsilateral to stimulation in the SSG. In addition, we observed activation of the corpus callosum and subcortical corticostriatal structures after stimulation. The results from the c-Fos mapping study were grossly consistent with the microPET imaging. Sensory-parietal cortex stimulation may therefore be a useful strategy for overcoming the limits of rehabilitative training in patients with severe forms of subcortical capsular infarct.

KEYWORDS:

Motor recovery; cortical stimulation; internal capsule; sensory-parietal cortex; stroke

PMID:
26661148
PMCID:
PMC5363658
DOI:
10.1177/0271678X15606136
[Indexed for MEDLINE]
Free PMC Article

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