Format

Send to

Choose Destination
Muscle Nerve. 2016 Jun;54(1):110-7. doi: 10.1002/mus.25015.

Muscle damage, metabolism, and oxidative stress in mdx mice: Impact of aerobic running.

Author information

1
Department of Human Sciences, Kinesiology Program, The Ohio State University, Columbus, Ohio, USA.
2
Department of Molecular & Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
3
Department of Physiology & Cell Biology, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
4
Deparment of Pharmacology, College of Medicine, The Ohio State University, Columbus, Ohio.

Abstract

INTRODUCTION:

We tested how a treadmill exercise program influences oxygen consumption, oxidative stress, and exercise capacity in the mdx mouse, a model of Duchenne muscular dystrophy.

METHODS:

At age 4 weeks mdx mice were subjected to 4 weeks of twice-weekly treadmill exercise. Sedentary mdx and wild-type mice served as controls. Oxygen consumption, time to exhaustion, oxidative stress, and myofiber damage were assessed.

RESULTS:

At age 4 weeks, there was a significant difference in exercise capacity between mdx and wild-type mice. After exercise, mdx mice had lower basal oxygen consumption and exercise capacity, but similar maximal oxygen consumption. Skeletal muscle from these mice displayed increased oxidative stress. Collagen deposition was higher in exercised versus sedentary mice.

CONCLUSIONS:

Exercised mdx mice exhibit increased oxidative stress, as well as deficits in exercise capacity, baseline oxygen consumption, and increased myofiber fibrosis. Muscle Nerve 54: 110-117, 2016.

KEYWORDS:

DMD; MDX; exercise; oxidative stress; oxygen consumption; treadmill

PMID:
26659868
PMCID:
PMC4905810
DOI:
10.1002/mus.25015
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center