Format

Send to

Choose Destination
J Clin Microbiol. 2016 Feb;54(2):259-64. doi: 10.1128/JCM.02419-15. Epub 2015 Dec 9.

Ultrasensitive Detection and Quantification of Toxins for Optimized Diagnosis of Clostridium difficile Infection.

Author information

1
Division of Infectious Diseases, Beth Israel Deaconess Medical Center, and Department of Laboratory Medicine, Boston Children's Hospital, Boston, Massachusetts, USA nira.pollock@childrens.harvard.edu.

Abstract

Recently developed ultrasensitive and quantitative methods for detection of Clostridium difficile toxins provide new tools for diagnosis and, potentially, for management of C. difficile infection (CDI). Compared to methods that detect toxigenic organism, ultrasensitive toxin detection may allow diagnosis of CDI with increased clinical specificity, without sacrificing clinical sensitivity; measurement of toxin levels may also provide information relevant to disease prognosis. This minireview provides an overview of these new toxin detection technologies and considers what these new tools might add to the field.

PMID:
26659205
PMCID:
PMC4733189
DOI:
10.1128/JCM.02419-15
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center