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Pediatr Infect Dis J. 2016 Apr;35(4):460-3. doi: 10.1097/INF.0000000000001041.

Vaccine Failures in Patients Properly Vaccinated with 13-Valent Pneumococcal Conjugate Vaccine in Catalonia, a Region with Low Vaccination Coverage.

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From the *Pediatrics, Hospital Vall d'Hebron, Barcelona, Spain; †Pediatrics, Hospital Sant Joan de Déu, Barcelona, Spain; ‡Pediatrics, Hospital de Nens, Barcelona, Spain; §Departament de Salut, Agència de Salut Pública de Catalunya, Barcelona, Spain; ¶Microbiology, Hospital Vall d'Hebron, Barcelona, Spain; ‖Preventive Medicine, Hospital Vall d'Hebron, Barcelona, Spain; **CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; ††Molecular Microbiology, Hospital Sant Joan de Déu, Barcelona, Spain; and ‡‡ Departament de Salut Pública, Universitat de Barcelona, Barcelona, Spain.


Vaccine failures occurring with 13-valent pneumococcal conjugate vaccine (PCV13) in 3 pediatric hospitals in Barcelona (2012-2013) are described. PCV13 vaccine failure was defined as the occurrence of an invasive pneumococcal infection in children properly vaccinated by PCV13. Among 84 patients with invasive pneumococcal infection, 32 had received at least one dose of PCV13. Seventeen of them had invasive pneumococcal infection produced by a PCV13 serotype. Among those, 9 patients were considered to have a PCV13 vaccine failure. Serotype 3 was isolated in 6 patients, serotype 19A in 2 and serotype 6B in 1.

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