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Biochem Biophys Res Commun. 1989 Jul 14;162(1):253-7.

Total synthesis of the lipopeptide a-mating factor of Saccharomyces cerevisiae.

Author information

1
Department of Chemistry, College of Staten Island, New York.

Abstract

The a-mating factor of Saccharomyces cerevisiae was synthesized using both solution phase and solid phase strategies. Structure of the final peptide was confirmed using amino acid analysis, fast atom bombardment mass spectroscopy and 400 MHz proton NMR. The synthetic farnesylated dodecapeptide, YIIKGVFWDPAC (S-farnesyl) OCH3, exhibited chromatographic and spectroscopic properties identical to the natural pheromone and had significant biological activity at nanomolar concentrations.

PMID:
2665738
DOI:
10.1016/0006-291x(89)91989-x
[Indexed for MEDLINE]

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