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Clin Microbiol Rev. 2016 Jan;29(1):191-9. doi: 10.1128/CMR.00063-15.

The Microbiome, Systemic Immune Function, and Allotransplantation.

Author information

1
Infectious Disease Division and Transplant Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
2
Infectious Disease Division and Transplant Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA jfishman@partners.org.

Abstract

Diverse effects of the microbiome on solid organ transplantation are beginning to be recognized. In allograft recipients, microbial networks are disrupted by immunosuppression, nosocomial and community-based infectious exposures, antimicrobial therapies, surgery, and immune processes. Shifting microbial patterns, including acute infectious exposures, have dynamic and reciprocal interactions with local and systemic immune systems. Both individual microbial species and microbial networks have central roles in the induction and control of innate and adaptive immune responses, in graft rejection, and in ischemia-reperfusion injury. Understanding the diverse interactions between the microbiome and the immune system of allograft recipients may facilitate clinical management in the future.

PMID:
26656674
PMCID:
PMC4771220
DOI:
10.1128/CMR.00063-15
[Indexed for MEDLINE]
Free PMC Article

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