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Cell Rep. 2015 Dec 1;13(9):1741-6. doi: 10.1016/j.celrep.2015.10.047. Epub 2015 Nov 19.

Activation of a Temporal Memory in Purkinje Cells by the mGluR7 Receptor.

Author information

1
Associative Learning Group, Department of Experimental Medical Science, Lund University, 22184 Lund, Sweden; The Linnaeus Center Thinking in Time: Cognition, Communication & Learning, Lund University, 22184 Lund, Sweden. Electronic address: fredrik.johansson@med.lu.se.
2
Associative Learning Group, Department of Experimental Medical Science, Lund University, 22184 Lund, Sweden.
3
Associative Learning Group, Department of Experimental Medical Science, Lund University, 22184 Lund, Sweden; The Linnaeus Center Thinking in Time: Cognition, Communication & Learning, Lund University, 22184 Lund, Sweden.
4
Department of Neuroscience, Physiology & Pharmacology, University College London, London WC1E 6BT, UK.

Abstract

Cerebellar Purkinje cells can learn to respond to a conditioned stimulus with an adaptively timed pause in firing. This response was usually ascribed to long-term depression of parallel fiber to Purkinje cell synapses but has recently been shown to be due to a previously unknown form of learning involving an intrinsic cellular timing mechanism. Here, we investigate how these responses are elicited. They are resistant to blockade of GABAergic inhibition, suggesting that they are caused by glutamate release rather than by a changed balance between GABA and glutamate. We show that the responses are abolished by antagonists of the mGlu7 receptor but not significantly affected by other glutamate antagonists. These results support the existence of a distinct learning mechanism, different from changes in synaptic strength. They also demonstrate in vivo post-synaptic inhibition mediated by glutamate and show that the mGlu7 receptor is involved in activating intrinsic temporal memory.

KEYWORDS:

Purkinje cell; cerebellum; classical conditioning; glutamate; mGluR1; mGluR7; temporal; timing

PMID:
26655894
DOI:
10.1016/j.celrep.2015.10.047
[Indexed for MEDLINE]
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