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Nat Rev Immunol. 2016 Jan;16(1):7-21. doi: 10.1038/nri.2015.7. Epub 2015 Dec 14.

Converging roles of caspases in inflammasome activation, cell death and innate immunity.

Author information

1
Department of Immunology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

Abstract

Inflammatory and apoptotic caspases are central players in inflammation and apoptosis, respectively. However, recent studies have revealed that these caspases have functions beyond their established roles. In addition to mediating cleavage of the inflammasome-associated cytokines interleukin-1β (IL-1β) and IL-18, inflammatory caspases modulate distinct forms of programmed cell death and coordinate cell-autonomous immunity and other fundamental cellular processes. Certain apoptotic caspases assemble structurally diverse and dynamic complexes that direct inflammasome and interferon responses to fine-tune inflammation. In this Review, we discuss the expanding and interconnected roles of caspases that highlight new aspects of this family of cysteine proteases in innate immunity.

PMID:
26655628
PMCID:
PMC4915362
DOI:
10.1038/nri.2015.7
[Indexed for MEDLINE]
Free PMC Article

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