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J Affect Disord. 2016 Feb;191:123-31. doi: 10.1016/j.jad.2015.11.012. Epub 2015 Nov 17.

Genome-wide linkage on chromosome 10q26 for a dimensional scale of major depression.

Author information

1
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; Olin Neuropsychiatric Research Center, Institute of Living, Hartford Hospital, Hartford, CT, USA. Electronic address: emma.knowles@yale.edu.
2
Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.
3
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; Olin Neuropsychiatric Research Center, Institute of Living, Hartford Hospital, Hartford, CT, USA.
4
South Texas Diabetes and Obesity Institute, University of Texas Health Science Center at San Antonio & University of Texas of the Rio Grande Valley, Brownsville, TX, United States.
5
Department of Psychiatry, University of Texas Health Science Center San Antonio, Texas Center San Antonio, San Antonio, TX, United States.
6
Research Imaging Institute, University of Texas Health Science Center San Antonio, San Antonio, TX, United States; South Texas Veterans' Healthcare System, 7400 Merton Minter, San Antonio, TX 78229, USA.

Abstract

Major depressive disorder (MDD) is a common and potentially life-threatening mood disorder. Identifying genetic markers for depression might provide reliable indicators of depression risk, which would, in turn, substantially improve detection, enabling earlier and more effective treatment. The aim of this study was to identify rare variants for depression, modeled as a continuous trait, using linkage and post-hoc association analysis. The sample comprised 1221 Mexican-American individuals from extended pedigrees. A single dimensional scale of MDD was derived using confirmatory factor analysis applied to all items from the Past Major Depressive Episode section of the Mini-International Neuropsychiatric Interview. Scores on this scale of depression were subjected to linkage analysis followed by QTL region-specific association analysis. Linkage analysis revealed a single genome-wide significant QTL (LOD=3.43) on 10q26.13, QTL-specific association analysis conducted in the entire sample revealed a suggestive variant within an intron of the gene LHPP (rs11245316, p=7.8×10(-04); LD-adjusted Bonferroni-corrected p=8.6×10(-05)). This region of the genome has previously been implicated in the etiology of MDD; the present study extends our understanding of the involvement of this region by highlighting a putative gene of interest (LHPP).

PMID:
26655122
PMCID:
PMC4715913
DOI:
10.1016/j.jad.2015.11.012
[Indexed for MEDLINE]
Free PMC Article

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