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J Dermatolog Treat. 2016 Aug;27(4):351-4. doi: 10.3109/09546634.2015.1117565. Epub 2015 Dec 10.

β-Glucan-based cream (containing pleuran isolated from pleurotus ostreatus) in supportive treatment of mild-to-moderate atopic dermatitis.

Author information

1
a Department of Paediatrics, Jessenius Faculty of Medicine , Comenius University in Bratislava , Martin , Slovakia .
2
b Department of Dermatology , Slovak Medical University , Banska Bystrica , Slovakia .
3
c Department of Microbiology, Faculty of Medicine , Slovak Medical University , Bratislava , Slovakia .
4
d Institute of Zoology, Slovak Academy of Sciences , Bratislava , Slovakia , and.
5
e Department of Dermatovenerology , Second School of Medicine, Bulovka University Hospital, Charles University , Prague , Czech Republic.

Abstract

BACKGROUND:

Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases with serious impact on quality of life. β-Glucans are natural substances with potent immunomodulatory and anti-inflammatory activity.

METHODS:

In a multicentre open split-body study, we studied the effect of Imunoglukan P4H® cream in a group of 105 patients with AD (39 males, 37%). Evaluation of subjective (visual analogue scale, VAS) and objective (EASI score, eczema area and severity index) characteristics of AD was carried out.

RESULTS:

In total, 80 patients (76.2%) completed the study. Topical β-glucan application resulted in the significant improvement of both objective and subjective symptoms of AD. On the application side, significant decline in the number of days with AD exacerbation and its severity was observed. Moreover, the subjects experienced decline of pruritus on the β-glucan half of the body (VAS score: 1.68 vs. 1.95, p < 0.001). During the study, the continual and significant decline of EASI scores on the site of β-glucan application was observed (V4: 1.57 vs. 1.85, p < 0.001). The preparation was in general well tolerated.

CONCLUSIONS:

This is the first study evaluating and confirming the potential use of β-glucan-based cream as a supportive complementary therapy of atopic dermatitis.

KEYWORDS:

atopic dermatitis; complementary medicine; pleuran; topical treatment; β-glucan

PMID:
26654776
DOI:
10.3109/09546634.2015.1117565
[Indexed for MEDLINE]

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