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Trends Cardiovasc Med. 2016 May;26(4):364-73. doi: 10.1016/j.tcm.2015.10.004. Epub 2015 Oct 31.

Metabolic syndrome update.

Author information

1
Department of Internal Medicine and Center for Human Nutrition, UT Southwestern Medical Center, Dallas, TX; Veterans Affairs Medical Center, Dallas, TX. Electronic address: scott.grundy@utsouthwestern.edu.

Abstract

The metabolic syndrome is a multiplex risk factor for atherosclerotic cardiovascular disease and type 2 diabetes. It is composed of atherogenic dyslipidemia, elevated blood pressure, insulin resistance and elevated glucose, a pro-thrombotic state, and a pro-inflammatory state. Excess energy intake and concomitant obesity are the major drivers of the syndrome. Lifestyle intervention can reverse metabolic risk factors, but at times, drug therapies or bariatric surgery may be required to control more overt risk factors.

KEYWORDS:

Diabetes; Dyslipidemia; Hypertension; Metabolic syndrome; Nutrition; Obesity

PMID:
26654259
DOI:
10.1016/j.tcm.2015.10.004
[Indexed for MEDLINE]

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