Format

Send to

Choose Destination
Nanomedicine (Lond). 2016 Jan;11(1):9-30. doi: 10.2217/nnm.15.183. Epub 2015 Dec 11.

EGCG/gelatin-doxorubicin gold nanoparticles enhance therapeutic efficacy of doxorubicin for prostate cancer treatment.

Author information

1
Institute of Organic & Polymeric Materials, National Taipei University of Technology, Taipei 10608, Taiwan.
2
Institute of Biomedical Engineering, National Taiwan University, Taipei 10002, Taiwan.
3
Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
4
Department of Biochemistry & Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei City 11031, Taiwan.
5
Graduate Institute of Nanomedicine & Medical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan.

Abstract

AIM:

Development of epigallocatechin gallate (EGCG) and gelatin-doxorubicin conjugate (GLT-DOX)-coated gold nanoparticles (DOX-GLT/EGCG AuNPs) for fluorescence imaging and inhibition of prostate cancer cell growth.

MATERIALS & METHODS:

AuNPs alternatively coated with EGCG and DOX-GLT conjugates were prepared by a layer-by-layer assembly method. The physicochemical properties of the AuNPs and the effect of Laminin 67R receptor-mediated endocytosis on the anticancer efficacy of the AuNPs were examined.

RESULTS:

The AuNPs significantly inhibit the proliferation of PC-3 cancer cell and the enzyme-responsive intracellular release of DOX could be tracked by monitoring the recovery of the fluorescence signal of DOX.

CONCLUSION:

Laminin 67R receptor-mediated delivery of DOX using the AuNPs enhanced cellular uptake of DOX and improved apoptosis of PC-3 cells.

KEYWORDS:

EGCG; Lam 67R; MMP-2; cellular uptake; doxorubicin; drug release; gelatin; gold nanoparticles; prostate cancer

PMID:
26654241
DOI:
10.2217/nnm.15.183
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center