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Eur J Paediatr Neurol. 2016 Jan;20(1):20-4. doi: 10.1016/j.ejpn.2015.11.002. Epub 2015 Nov 11.

Prevalence and clinical implications of renal artery stenosis in pediatric moyamoya disease.

Author information

1
Department of Radiology, Samsung Medical Center, Sunkyunkwan University School of Medicine, Seoul, Republic of Korea; Department of Radiology, Inje University College of Medicine, Busan Paik Hospital, Republic of Korea.
2
Department of Neurosurgery, Samsung Medical Center, Sunkyunkwan University School of Medicine, Seoul, Republic of Korea.
3
Department of Radiology, Samsung Medical Center, Sunkyunkwan University School of Medicine, Seoul, Republic of Korea.
4
Department of Radiology, Samsung Medical Center, Sunkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address: drsomatom@gmail.com.

Abstract

PURPOSE:

Until recently, extracranial involvement of moyamoya disease (MMD) had not been fully elucidated. The purpose of this study was to determine the prevalence and clinical implications of renal artery stenosis in pediatric MMD patients.

MATERIALS & METHODS:

This retrospective study included 101 pediatric (<18 years old) MMD patients who visited our hospital from July 2008 to May 2013. All patients had legible abdominal or renal angiography. Baseline characteristics, including hypertension (HT) and angiographic findings, were retrospectively evaluated.

RESULT:

The median age was 8 (range 2-16) years. Six patients (5.9%) had HT. Renal artery stenosis was identified in 8 patients (7.9%). Five of 8 renal artery stenosis patients had HT. Statistical analysis showed that advanced stages of MMD and HT were associated with renal artery stenosis (p < 0.05).

CONCLUSION:

Renal artery stenosis was not uncommon in pediatric MMD. Renal artery evaluation could help determine the cause of HT in advanced pediatric MMD cases. Further prospective and large-scale studies may be helpful in elucidating the extracranial manifestation of MMD.

KEYWORDS:

Moyamoya disease; Prevalence; Renal artery obstruction

PMID:
26652853
DOI:
10.1016/j.ejpn.2015.11.002
[Indexed for MEDLINE]

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