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Mater Sci Eng C Mater Biol Appl. 2016 Feb;59:1181-1194. doi: 10.1016/j.msec.2015.11.026. Epub 2015 Nov 11.

Fabrication of functional PLGA-based electrospun scaffolds and their applications in biomedical engineering.

Author information

1
Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi, China. Electronic address: wenzhao@nwpu.edu.cn.
2
Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi, China.
3
Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Abstract

Electrospun PLGA-based scaffolds have been applied extensively in biomedical engineering, such as tissue engineering and drug delivery system. Due to lack of the recognition sites on cells, hydropholicity and single-function, the applications of PLGA fibrous scaffolds are limited. In order to tackle these issues, many works have been done to obtain functional PLGA-based scaffolds, including surface modifications, the fabrication of PLGA-based composite scaffolds and drug-loaded scaffolds. The functional PLGA-based scaffolds have significantly improved cell adhesion, attachment and proliferation. Moreover, the current study has summarized the applications of functional PLGA-based scaffolds in wound dressing, vascular and bone tissue engineering area as well as drug delivery system.

KEYWORDS:

Applications; Biomedical engineering; Drug delivery; Electrospun; PLGA; Tissue engineering

PMID:
26652474
DOI:
10.1016/j.msec.2015.11.026
[Indexed for MEDLINE]

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