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Cell Host Microbe. 2015 Dec 9;18(6):659-69. doi: 10.1016/j.chom.2015.11.008.

Evolution and Spread of Ebola Virus in Liberia, 2014-2015.

Author information

1
Center for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD, 21702, USA. Electronic address: jason.t.ladner.ctr@mail.mil.
2
Center for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD, 21702, USA.
3
Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, Charlotte Auerbach Road, Edinburgh EH9 3FL, UK.
4
Molecular and Translational Sciences Division, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD, 21702, USA.
5
Liberian Institute for Biomedical Research, Charlesville, Liberia.
6
Naval Medical Research Unit 3, 3A Imtidad Ramses Street, Cairo, Egypt 11517.
7
Diagnostic Systems Division, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD, 21702, USA.
8
MRI Global, 1330 Piccard Avenue, Rockville, MD, 20850, USA; The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
9
Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, NIH, B-8200 Research Plaza, Fort Detrick, Frederick, MD, 21702, USA.
10
Broad Institute, 75 Ames St, Cambridge, MA, 02142, USA.
11
Broad Institute, 75 Ames St, Cambridge, MA, 02142, USA; Harvard University, 52 Oxford Street, Cambridge, MA, 02138, USA.
12
Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, Charlotte Auerbach Road, Edinburgh EH9 3FL, UK; Centre for Immunology, Infection and Evolution, University of Edinburgh, Ashworth Laboratories, Charlotte Auerbach Road, Edinburgh EH9 3FL, UK; Fogarty International Center, NIH, 31 Center Drive, Bethesda, MD, 20892, USA.
13
Center for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD, 21702, USA. Electronic address: gustavo.f.palacios.ctr@mail.mil.

Abstract

The 2013-present Western African Ebola virus disease (EVD) outbreak is the largest ever recorded with >28,000 reported cases. Ebola virus (EBOV) genome sequencing has played an important role throughout this outbreak; however, relatively few sequences have been determined from patients in Liberia, the second worst-affected country. Here, we report 140 EBOV genome sequences from the second wave of the Liberian outbreak and analyze them in combination with 782 previously published sequences from throughout the Western African outbreak. While multiple early introductions of EBOV to Liberia are evident, the majority of Liberian EVD cases are consistent with a single introduction, followed by spread and diversification within the country. Movement of the virus within Liberia was widespread, and reintroductions from Liberia served as an important source for the continuation of the already ongoing EVD outbreak in Guinea. Overall, little evidence was found for incremental adaptation of EBOV to the human host.

PMID:
26651942
PMCID:
PMC4711363
DOI:
10.1016/j.chom.2015.11.008
[Indexed for MEDLINE]
Free PMC Article

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