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Trends Plant Sci. 2016 Apr;21(4):302-316. doi: 10.1016/j.tplants.2015.10.019. Epub 2015 Dec 1.

Structural Biology of Nuclear Auxin Action.

Author information

1
Department of Molecular Signal Processing, Leibniz Institute of Plant Biochemistry, Weinberg 3, D-06120 Halle (Saale), Germany.
2
Department of Molecular Signal Processing, Leibniz Institute of Plant Biochemistry, Weinberg 3, D-06120 Halle (Saale), Germany; Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Strasse 3, D-06120 Halle (Saale), Germany; Department of Plant Sciences, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA. Electronic address: sabel@ipb-halle.de.

Abstract

Auxin coordinates plant development largely via hierarchical control of gene expression. During the past decades, the study of early auxin genes paired with the power of Arabidopsis genetics have unraveled key nuclear components and molecular interactions that perceive the hormone and activate primary response genes. Recent research in the realm of structural biology allowed unprecedented insight into: (i) the recognition of auxin-responsive DNA elements by auxin transcription factors; (ii) the inactivation of those auxin response factors by early auxin-inducible repressors; and (iii) the activation of target genes by auxin-triggered repressor degradation. The biophysical studies reviewed here provide an impetus for elucidating the molecular determinants of the intricate interactions between core components of the nuclear auxin response module.

KEYWORDS:

auxin perception; auxin signaling; structural biology; transcription factors

PMID:
26651917
DOI:
10.1016/j.tplants.2015.10.019
[Indexed for MEDLINE]

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