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Dev Cell. 2015 Dec 7;35(5):531-532. doi: 10.1016/j.devcel.2015.11.014.

Liquids, Fibers, and Gels: The Many Phases of Neurodegeneration.

Author information

1
Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA.
2
Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA. Electronic address: cbrangwy@princeton.edu.

Abstract

Recent advances suggest that phase transitions of proteins into liquid or hydrogel states could underlie pathological protein aggregation associated with neurodegenerative disease. In a recent issue of Neuron, Murakami et al. (2015) demonstrate that ALS-associated FUS mutations abrogate the reversibility of condensed liquids and/or hydrogels, leading to neurotoxicity in C. elegans.

PMID:
26651288
DOI:
10.1016/j.devcel.2015.11.014
[Indexed for MEDLINE]
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