Format

Send to

Choose Destination
Best Pract Res Clin Gastroenterol. 2015 Dec;29(6):919-28. doi: 10.1016/j.bpg.2015.09.007. Epub 2015 Sep 10.

Changing epidemiology of hepatocellular carcinoma in Asia.

Author information

1
Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore; Duke-NUS Graduate Medical School, Singapore. Electronic address: george.goh.b.b@sgh.com.sg.
2
Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore; Duke-NUS Graduate Medical School, Singapore. Electronic address: jason.chang@sgh.com.sg.
3
Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore; Duke-NUS Graduate Medical School, Singapore. Electronic address: tan.chee.kiat@sgh.com.sg.

Abstract

Hepatocellular carcinoma is a major problem in Asia because of the presence of multiple risk factors in the region such as endemicity of hepatitis B and significant contamination of foodstuff by aflatoxin in some areas. Another risk factor for HCC, chronic hepatitis C infection, in Asia is most significant in Japan, the only Asian country with more HCV than HBV-related hepatocellular carcinoma. As these risk factors can and are being modified by measures such as universal hepatitis B immunisation, successful treatment of HCV infections, reduction and improved surveillance of aflatoxin contamination of foodstuff, it is not surprising that the epidemiology of HCC in Asia is changing. All these are offset by the rising importance of NAFLD and NASH as chronic liver diseases and risk factors for HCC which contributes to the changing epidemiology of HCC in Asia.

KEYWORDS:

Aflatoxin; Epidemiology; Hepatitis B; Hepatitis C; Hepatocellular carcinoma; Non-alcoholic steatohepatitis NASH

PMID:
26651253
DOI:
10.1016/j.bpg.2015.09.007
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center