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Blood Coagul Fibrinolysis. 2016 Sep;27(6):727-8. doi: 10.1097/MBC.0000000000000473.

Postpartum haemorrhage in a woman with essential thrombocythemia carrying calreticulin mutation: a case report.

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aAtherosclerosis and Thrombosis Unit bHematology Department, I.R.C.C.S. 'Casa Sollievo della Sofferenza', S. Giovanni Rotondo (Foggia), Italy.


Coagulation disorder associated with essential thrombocythemia may exacerbate the prothrombotic state physiologically occurring during pregnancy. We report a case of a severe postpartum haemorrhage in a 35-year-old woman previously diagnosed with essential thrombocythemia and carrying the somatic calreticulin mutation. She was referred to our Thrombosis and Haemostasis Unit for pregnancy management. A treatment with low-dose aspirin was prescribed until the labour started, as the platelets count raised above 1000 × 10/l. At the time of bleeding, no residual placenta was detected at the revision of the uterine cavity.Although the postpartum is a high-risk period for thrombotic events, we have to carefully evaluate in women with essential thrombocythemia the likelihood of developing a hemorrhagic complication.

[Indexed for MEDLINE]

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