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Br J Pharmacol. 2015 Dec;172(24):5942-55. doi: 10.1111/bph.13351.

The Concise Guide to PHARMACOLOGY 2015/16: Other ion channels.

Author information

  • 1School of Biomedical Sciences, University of Nottingham Medical School, Nottingham,, NG7 2UH, UK.
  • 2School of Physiology and Pharmacology, University of Bristol, Bristol, BS8 1TD, UK.
  • 3Neuroscience Division, Medical Education Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK.
  • 4Centre for Integrative Physiology, University of Edinburgh, Edinburgh, EH8 9XD, UK.

Abstract

The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. The full contents can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13351/full. Other ion channels are one of the eight major pharmacological targets into which the Guide is divided, with the others being: G protein-coupled receptors, ligand-gated ion channels, voltage-gated ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The Concise Guide is published in landscape format in order to facilitate comparison of related targets. It is a condensed version of material contemporary to late 2015, which is presented in greater detail and constantly updated on the website www.guidetopharmacology.org, superseding data presented in the previous Guides to Receptors & Channels and the Concise Guide to PHARMACOLOGY 2013/14. It is produced in conjunction with NC-IUPHAR and provides the official IUPHAR classification and nomenclature for human drug targets, where appropriate. It consolidates information previously curated and displayed separately in IUPHAR-DB and GRAC and provides a permanent, citable, point-in-time record that will survive database updates.

PMID:
26650442
PMCID:
PMC4718214
DOI:
10.1111/bph.13351
[PubMed - indexed for MEDLINE]
Free PMC Article
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