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Br J Pharmacol. 2015 Dec;172(24):5729-43. doi: 10.1111/bph.13347.

The Concise Guide to PHARMACOLOGY 2015/16: Overview.

Collaborators (141)

Aldrich R, Attali B, Bäck ML, Barnes NM, Bathgate R, Beart PM, Becirovic E, Biel M, Birdsall NJ, Boison D, Bräuner-Osborne H, Bröer S, Bryant C, Burnstock G, Burris T, Cain D, Calo G, Chan SL, Chandy KG, Chiang N, Christakos S, Christopoulos A, Chun JJ, Chung JJ, Clapham DE, Connor MA, Coons L, Cox HM, Dautzenberg FM, Dent G, Douglas SD, Dubocovich ML, Edwards DP, Farndale R, Fong TM, Forrest D, Fowler CJ, Fuller P, Gainetdinov RR, Gershengorn MA, Goldin A, Goldstein SA, Grimm SL, Grissmer S, Gundlach AL, Hagenbuch B, Hammond JR, Hancox JC, Hartig S, Hauger RL, Hay DL, Hébert T, Hollenberg AN, Holliday ND, Hoyer D, Ijzerman AP, Inui KI, Ishii S, Jacobson KA, Jan LY, Jarvis GE, Jensen R, Jetten A, Jockers R, Kaczmarek LK, Kanai Y, Kang HS, Karnik S, Kerr ID, Korach KS, Lange CA, Larhammar D, Leeb-Lundberg F, Leurs R, Lolait SJ, Macewan D, Maguire JJ, May JM, Mazella J, Mcardle CA, Mcdonnell DP, Michel MC, Miller LJ, Mitolo V, Monie T, Monk PN, Mouillac B, Murphy PM, Nahon JL, Nerbonne J, Nichols CG, Norel X, Oakley R, Offermanns S, Palmer LG, Panaro MA, Perez-Reyes E, Pertwee RG, Pike JW, Pin JP, Pintor S, Plant LD, Poyner DR, Prossnitz ER, Pyne S, Ren D, Richer JK, Rondard P, Ross RA, Sackin H, Safi R, Sanguinetti MC, Sartorius CA, Segaloff DL, Sladek FM, Stewart G, Stoddart LA, Striessnig J, Summers RJ, Takeda Y, Tetel M, Toll L, Trimmer JS, Tsai MJ, Tsai SY, Tucker S, Usdin TB, Vilargada JP, Vore M, Ward DT, Waxman SG, Webb P, Wei AD, Weigel N, Willars GB, Winrow C, Wong SS, Wulff H, Ye RD, Young M, Zajac JM.

Author information

1
School of Biomedical Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK.
2
School of Physiology and Pharmacology, University of Bristol, Bristol, BS8 1TD, UK.
3
Neuroscience Division, Medical Education Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK.
4
Centre for Integrative Physiology, University of Edinburgh, Edinburgh, EH8 9XD, UK.
5
Laboratory for Foundations of Computer Science, School of Informatics, University of Edinburgh, Edinburgh, EH8 9LE, United Kingdom.
6
Department of Pharmacology, University of Washington, Seattle, 98195-7280, WA, USA.
7
National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, 27709, NC, USA.
8
Clinical Pharmacology Unit, University of Cambridge, Cambridge, CB2 0QQ, UK.
9
PIQUR Therapeutics, Basel, 4057, Switzerland.
10
The Agnes Irwin School, Rosemont, Pennsylvania, USA.
11
School of Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.
12
Spedding Research Solutions SARL, Le Vésinet, 78110, France.

Abstract

The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. The full contents can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13347/full. This compilation of the major pharmacological targets is divided into eight areas of focus: G protein-coupled receptors, ligand-gated ion channels, voltage-gated ion channels, other ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The Concise Guide is published in landscape format in order to facilitate comparison of related targets. It is a condensed version of material contemporary to late 2015, which is presented in greater detail and constantly updated on the website www.guidetopharmacology.org, superseding data presented in the previous Guides to Receptors & Channels and the Concise Guide to PHARMACOLOGY 2013/14. It is produced in conjunction with NC-IUPHAR and provides the official IUPHAR classification and nomenclature for human drug targets, where appropriate. It consolidates information previously curated and displayed separately in IUPHAR-DB and GRAC and provides a permanent, citable, point-in-time record that will survive database updates.

PMID:
26650438
PMCID:
PMC4718217
DOI:
10.1111/bph.13347
[Indexed for MEDLINE]
Free PMC Article

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