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Adv Mater. 2016 Feb 17;28(7):1472-6. doi: 10.1002/adma.201504995. Epub 2015 Dec 9.

Combinatorial Biomolecular Nanopatterning for High-Throughput Screening of Stem-Cell Behavior.

Author information

1
Interdisciplinary Nanoscience Center (iNANO), Faculty of Science and Technology, Aarhus University, 8000, Aarhus C, Denmark.
2
Laboratory of Biophysics and Surface Analysis, School of Pharmacy, University of Nottingham, NG7 2RD, Nottingham, UK.
3
Department of Chemical Sciences, University of Padova, 35122, Padova, Italy.
4
Department of Dentistry, Faculty of Health, Aarhus University, 8000, Aarhus C, Denmark.

Abstract

A novel combinatorial biomolecular nanopatterning method is reported, in which multiple biomolecular ligands can be patterned in multiple nanoscale dimensions on a single surface. The applicability of the combinatorial platform toward cell-biology applications is demonstrated by screening the adhesion behavior of a population of human dental pulp stem cell (hDPSC) on 64 combinations of nanopatterned extracellular matrix (ECM) proteins in parallel.

KEYWORDS:

cell adhesion; combinatorial; high throughput; nanofabrication; protein patterning

PMID:
26650176
DOI:
10.1002/adma.201504995
[Indexed for MEDLINE]

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