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Autophagy. 2015 Nov 2;11(11):2132-2133.

A molecular switch for selective autophagosome formation.

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a Northwest Labs ; Department of Molecular and Cellular Biology ; Harvard University ; Cambridge , MA USA.


Selective macroautophagy (hereafter autophagy) can eliminate large cytotoxic structures that are designated for degradation by autophagy receptors. In our recent paper, we showed that a key function of target-bound autophagy receptors is to activate the autophagy kinase, Atg1, via interactions with the scaffold protein Atg11. Our work thus reveals a mechanism by which target recognition coordinates the earliest steps in autophagosome biogenesis.


Ape1; Atg1; Atg11; Atg19; Atg36; autophagosome formation; pexophagy; phagophore; selective autophagy

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