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Pak J Med Sci. 2015 Sep-Oct;31(5):1246-9. doi: 10.12669/pjms.315.7888.

The prevalence of HTLV-1 and its Co-Infection with HCV, HBV and HIV in Hemophilic patients.

Author information

1
Masood Ziaee, Hepatitis Research Center, Birjand University of Medical Sciences, Birjand, Iran.
2
Mohammad Hassan Namaei, Hepatitis Research Center, Birjand University of Medical Sciences, Birjand, Iran.
3
Ghodseh Azarkar, Hepatitis Research Center, Birjand University of Medical Sciences, Birjand, Iran.

Abstract

BACKGROUND AND OBJECTIVE:

Blood-borne infections, such as the HIV virus and hepatitis B and C, are major problems in patients receiving blood products. Here we examined the prevalence of HTLV-1, HCV, HBV, and HIV in hemophilic patients.

METHODS:

A cross-sectional study on 108 hemophilic patients (101 males and 7 females) involved detection of HBV, HCV, HIV and HTLV-1 infections using immunoassays for HBsAg, hepatitis B core antibodies (anti-HBc), hepatitis C antibodies (anti-HCV), HIV antibodies (anti-HIV) and Anti-HTLV-1. Real-time PCR was used to measure HCV RNA, and HCV genotyping was performed by direct sequencing of the 5' noncoding region.

RESULTS:

Hemophilia A was reported in 93 (86%) patients with severe symptoms in 8 cases. The seroprevalence of anti-HCV and anti-HTLV-1 antibodies was 20% and 3% respectively. One patient with severe hemophilia had a HCV/HTLV-1 co-infection. HCV-RNA was detected in 82% of patients. In terms of genotyping prevalence was 56% HCV genotype 3a, 39% HCV genotype 1a, and 6% HCV genotype2. Anti HIV and HBsAg were not detected in any patient. HTLV1 prevalence was higher, HCV lower in South Khorasan than other regions in Iran or elsewhere.

CONCLUSION:

Management of transfusion of blood and blood products should account for the underlying prevalence of infectious agents.

KEYWORDS:

HTLV-1; Hemophilia; Hepatitis B Virus; Hepatitis C virus; Transfusion-Transmitted Virus

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