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Prostaglandins. 1989 Mar;37(3):311-5.

Pronounced reduction of in vivo prostacyclin synthesis in humans by acetaminophen (paracetamol).

Author information

1
Department of Clinical Chemistry and Blood Coagulation, Karolinska Hospital, Stockholm, Sweden.

Abstract

The effect of a single dose of 500 mg acetaminophen (paracetamol) on the in vivo synthesis of prostacyclin was studied in healthy volunteers by measurements of the urinary excretion of 2,3-dinor-6-keto-PGF1 alpha. Acetaminophen caused a marked reduction of prostacyclin synthesis for 6-8 hours without any obvious effect on the thromboxane synthesis. Thus, acetaminophen may at least theoretically be disadvantageous for patients suffering from diseases where prostacyclin mediated vascular defence mechanisms are activated, like myocardial infarction, deep vein thrombosis and following surgery.

PMID:
2664901
DOI:
10.1016/0090-6980(89)90001-4
[Indexed for MEDLINE]

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