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Sci Rep. 2015 Dec 9;5:17847. doi: 10.1038/srep17847.

Experience-dependent emergence of beta and gamma band oscillations in the primary visual cortex during the critical period.

Author information

1
Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
2
State Key Laboratory of Cognitive Neuroscience &Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China.
3
University of Chinese Academy of Sciences, Shanghai, China.

Abstract

Neural oscillatory activities have been shown to play important roles in neural information processing and the shaping of circuit connections during development. However, it remains unknown whether and how specific neural oscillations emerge during a postnatal critical period (CP), in which neuronal connections are most substantially modified by neural activity and experience. By recording local field potentials (LFPs) and single unit activity in developing primary visual cortex (V1) of head-fixed awake mice, we here demonstrate an emergence of characteristic oscillatory activities during the CP. From the pre-CP to CP, the peak frequency of spontaneous fast oscillatory activities shifts from the beta band (15-35 Hz) to the gamma band (40-70 Hz), accompanied by a decrease of cross-frequency coupling (CFC) and broadband spike-field coherence (SFC). Moreover, visual stimulation induced a large increase of beta-band activity but a reduction of gamma-band activity specifically from the CP onwards. Dark rearing of animals from the birth delayed this emergence of oscillatory activities during the CP, suggesting its dependence on early visual experience. These findings suggest that the characteristic neuronal oscillatory activities emerged specifically during the CP may represent as neural activity trait markers for the experience-dependent maturation of developing visual cortical circuits.

PMID:
26648548
PMCID:
PMC4673459
DOI:
10.1038/srep17847
[Indexed for MEDLINE]
Free PMC Article

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