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IET Nanobiotechnol. 2015 Dec;9(6):368-74. doi: 10.1049/iet-nbt.2014.0075.

In vivo evaluation of the biodistribution of intravenously administered naked and functionalised silver nanoparticles in rabbit.

Author information

1
Physics Department, University of Engineering and Technology, Lahore, Pakistan. ayesha.ashraf87@hotmail.com.
2
Physics Department, University of Engineering and Technology, Lahore, Pakistan.
3
Institute of Nuclear Medicine and Oncology (INMOL), Lahore, Pakistan.
4
Advanced Nanofabrication Imaging and Characterization Laboratory, King Abdullah University of Science and Technology, Thuwal/Jeddah, Saudi Arabia.

Abstract

Water-based suspension of silver nanoparticles (AgNPs) and dextran coated AgNPs (dextran-AgNPs) are fabricated and characterised for intravenous administration. A simple method for radiolabelling of nanoparticles with (99m)Tc was used. Labelling efficiency for AgNPs and dextran-AgNPs was found to be more than 80 and 88%, respectively. In vivo tissue uptake of nanoparticles during dynamic phase, after systematic administration by biodistribution analysis with single-photon emission computed tomography imaging has been evaluated. Biodistribution analysis revealed that (99m)Tc-AgNPs and (99m)Tc-dextran-AgNPs are mainly accumulated in liver/spleen region but (99m)Tc-dextran-AgNPs delayed recognition and uptake by liver. Results indicate that dextran-AgNPs are able to evade reticuloendothelum system with enhanced blood retention time. Accumulation of nanoparticles in liver/spleen region implicates the utilisation of AgNPs for liver cancer treatment.

PMID:
26647813
DOI:
10.1049/iet-nbt.2014.0075
[Indexed for MEDLINE]

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