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Expert Rev Anti Infect Ther. 2015;13(12):1499-516. doi: 10.1586/14787210.2015.1100533. Epub 2015 Nov 13.

Prevention and treatment of Staphylococcus aureus biofilms.

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a Department of Microbiology , The Ohio State University , Columbus , OH , USA.
b Department of Microbial Infection and Immunity , The Ohio State University College of Medicine , Columbus , OH , USA.
c The Center for Microbial Interface Biology, The Ohio State University , Columbus , OH , USA.
d Department of Orthopedics , The Ohio State University College of Medicine , Columbus , OH , USA.
e Department of Engineering Sciences, National Centre for Advanced Tribology at Southampton (nCATS) , University of Southampton , Southampton , UK.


S. aureus colonizes both artificial and tissue surfaces in humans causing chronic persistent infections that are difficult to cure. It is a notorious pathogen due to its antibiotic recalcitrance and phenotypic adaptability, both of which are facilitated by its ability to develop biofilms. S. aureus biofilms challenge conventional anti-infective approaches, most notably antibiotic therapy. Therefore there is an unmet need to develop and include parallel approaches that target S. aureus biofilm infections. This review discusses two broad anti-infective strategies: (1) preventative approaches (anti-biofilm surface coatings, the inclusion of biofilm-specific vaccine antigens); and (2) approaches aimed at eradicating established S. aureus biofilms, particularly those associated with implant infections. Advances in understanding the distinct nature of S. aureus biofilm development and pathogenesis have led to growing optimism in S. aureus biofilm targeted anti-infective strategies. Further research is needed however, to see the successful administration and validation of these approaches to the diverse types of infections caused by S. aureus biofilms from multiple clinical strains.


Staphylococcus aureus; anti-infective strategies; antibiotic tolerance; biofilm infections; device related infections; persistence; prosthetic implants

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