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PLoS One. 2015 Dec 8;10(12):e0143931. doi: 10.1371/journal.pone.0143931. eCollection 2015.

Isoflurane Post-Treatment Improves Outcome after an Embolic Stroke in Rabbits.

Author information

1
Department of Anesthesiology, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
2
Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
3
Department of Anesthesiology, University of Virginia, Charlottesville, Virginia, United States of America.

Abstract

Application of commonly used volatile anesthetics after brain ischemia onset (post-treatment) provides neuroprotection in rodents. To further test its translational potential, this study was designed to determine whether isoflurane post-treatment induced neuroprotection in rabbits after embolic stroke. White male New Zealand rabbits received intra-carotid injection of clots when they were awake. Some rabbits were exposed to 2.5% isoflurane for 1 h at 5 min after the injection. Isoflurane post-treatment increased the tolerance of rabbits to the amount of clots. Isoflurane post-treatment also reduced brain infarct volumes and plasma S100B 3 days after the injection of 5 mg clots and improved neurological deficit scores after the stroke. Isoflurane post-treatment improves neurological outcome in rabbits after embolic stroke.

PMID:
26645542
PMCID:
PMC4672898
DOI:
10.1371/journal.pone.0143931
[Indexed for MEDLINE]
Free PMC Article

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