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BMC Neurol. 2015 Dec 9;15:253. doi: 10.1186/s12883-015-0505-z.

Factors for short-term outcomes in patients with a minor stroke: results from China National Stroke Registry.

Wu L1, Wang A2,3,4,5,6, Wang X7,8,9,10, Zhao X11,12,13,14, Wang C15,16,17,18, Liu L19,20,21,22, Zheng H23,24,25,26, Wang Y27,28,29,30, Cao Y31, Wang Y32,33,34,35; China National Stroke Registry investigators.

Author information

1
Graduate School, North China University of Science and Technology, Tangshan, China. 15133916062@163.com.
2
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. anxin0907@163.com.
3
China National Clinical Research Center for Neurological Diseases, Beijing, China. anxin0907@163.com.
4
Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China. anxin0907@163.com.
5
Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China. anxin0907@163.com.
6
Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China. anxin0907@163.com.
7
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. xianweiw2005@gmail.com.
8
China National Clinical Research Center for Neurological Diseases, Beijing, China. xianweiw2005@gmail.com.
9
Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China. xianweiw2005@gmail.com.
10
Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China. xianweiw2005@gmail.com.
11
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. zxq@vip.163.com.
12
China National Clinical Research Center for Neurological Diseases, Beijing, China. zxq@vip.163.com.
13
Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China. zxq@vip.163.com.
14
Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China. zxq@vip.163.com.
15
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. snowsen@126.com.
16
China National Clinical Research Center for Neurological Diseases, Beijing, China. snowsen@126.com.
17
Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China. snowsen@126.com.
18
Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China. snowsen@126.com.
19
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. lipingsister@gmail.com.
20
China National Clinical Research Center for Neurological Diseases, Beijing, China. lipingsister@gmail.com.
21
Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China. lipingsister@gmail.com.
22
Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China. lipingsister@gmail.com.
23
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. zhgdoc@163.com.
24
China National Clinical Research Center for Neurological Diseases, Beijing, China. zhgdoc@163.com.
25
Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China. zhgdoc@163.com.
26
Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China. zhgdoc@163.com.
27
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. yongjunwang1962@gmail.com.
28
China National Clinical Research Center for Neurological Diseases, Beijing, China. yongjunwang1962@gmail.com.
29
Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China. yongjunwang1962@gmail.com.
30
Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China. yongjunwang1962@gmail.com.
31
Department of Neurology, Tangshan Gongren Hospital, Tangshan, China. yibin07@sina.com.
32
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. yilong528@gmail.com.
33
China National Clinical Research Center for Neurological Diseases, Beijing, China. yilong528@gmail.com.
34
Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China. yilong528@gmail.com.
35
Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China. yilong528@gmail.com.

Abstract

BACKGROUND:

Stroke recurrence and disability in patients with a minor stroke is one of the most depressing medical situations. In this study, we aimed to identify which factors were associated with adverse outcomes of a minor stroke.

METHODS:

The China National Stroke Registry (CNSR) is a nationwide prospective registry for patients presented to hospitals with acute cerebrovascular events between September 2007 and August 2008. The 3-month follow-up was completed in 4669 patients with a minor stroke defined as the initial neurological severity lower than 4 in the National Institutes of Health Stroke Scale (NIHSS). Multivariate model was used to determine the association between risk factors and clinical outcomes.

RESULTS:

Of 4669 patients with a minor stroke during 3-month follow-up, 459 (9.8 %) patients experienced recurrent stroke, 679 (14.5 %) had stroke disability and 168 (3.6 %) died. Multivariate model identified hypertension, diabetes mellitus, atrial fibrillation, coronary heart disease and previous stroke as independent predictors for the recurrent stroke. Age, diabetes mellitus, atrial fibrillation, previous stroke and time from onset to admission < 24 h were independent predictors for stroke disability. The independent predictors for the all-caused death were age, atrial fibrillation, and coronary heart disease.

CONCLUSIONS:

The short-term risk of poor clinical outcome in Chinese patients with a minor stroke was substantial. Therefore, patients with a minor stroke should be given expeditious assessment and urgent aggressive intervention.

PMID:
26645312
PMCID:
PMC4673844
DOI:
10.1186/s12883-015-0505-z
[Indexed for MEDLINE]
Free PMC Article

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