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Adv Mater. 2016 Feb 17;28(7):1387-93. doi: 10.1002/adma.201503893. Epub 2015 Dec 8.

Dietary Iron Oxide Nanoparticles Delay Aging and Ameliorate Neurodegeneration in Drosophila.

Zhang Y1, Wang Z2,3, Li X2,3, Wang L1, Yin M1, Wang L1, Chen N1, Fan C1,4, Song H2,3.

Author information

1
Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China.
2
Key Laboratory of Food Safety Research, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
3
Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, 100021, China.
4
School of Life Science & Technology, ShanghaiTech University, Shanghai, 201210, China.

Abstract

Dietary iron oxide nanoparticles are shown to ameliorate neurodegeneration in a Drosophelia Alzheimer's disease model. Iron oxide nanoparticles can mimic catalase and can decompose reactive oxygen species (ROS). This has potential therapeutic uses for aging, metabolic disorders, and neurodegenerative diseases, in which increased production of ROS is closely implicated.

KEYWORDS:

catalase mimics; iron oxide nanoparticles; neurodegeneration; oxidative stress

PMID:
26643597
DOI:
10.1002/adma.201503893
[Indexed for MEDLINE]

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