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Nat Neurosci. 2016 Jan;19(1):34-6. doi: 10.1038/nn.4187. Epub 2015 Dec 7.

Action initiation shapes mesolimbic dopamine encoding of future rewards.

Author information

1
Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
2
Medical Research Council Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, Oxford, UK.
3
Department of Experimental Psychology, University of Oxford, Oxford, UK.

Abstract

It is widely held that dopamine signaling encodes predictions of future rewards and such predictions are regularly used to drive behavior, but the relationship between these two is poorly defined. We found in rats that nucleus accumbens dopamine following a reward-predicting cue was attenuated unless movement was correctly initiated. Our results indicate that dopamine release in this region is contingent on correct action initiation and not just reward prediction.

PMID:
26642087
PMCID:
PMC4697363
DOI:
10.1038/nn.4187
[Indexed for MEDLINE]
Free PMC Article

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