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Clin Med Insights Oncol. 2015 Nov 25;9:113-21. doi: 10.4137/CMO.S29462. eCollection 2015.

Galectin-3 as a Potential Target to Prevent Cancer Metastasis.

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President and Chief Scientific Officer, GlycoMantra, Inc., Aldie, VA, USA.
Department of Histology and Cytology, Zagazig University, Zagazig, Egypt.


Interactions between two cells or between cell and extracellular matrix mediated by protein-carbohydrate interactions play pivotal roles in modulating various biological processes such as growth regulation, immune function, cancer metastasis, and apoptosis. Galectin-3, a member of the β-galactoside-binding lectin family, is involved in fibrosis as well as cancer progression and metastasis, but the detailed mechanisms of its functions remain elusive. This review discusses its structure, carbohydrate-binding properties, and involvement in various aspects of tumorigenesis and some potential carbohydrate ligands that are currently investigated to block galectin-3 activity.


TF disaccharide; angiogenesis; apoptosis; galectin-3; tumorigenesis

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