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J Endocrinol Invest. 1989 Apr;12(4):273-5.

Vacor inhibits insulin release from islets in vitro.

Author information

1
Second Department of Internal Medicine, Kobe University School of Medicine, Japan.

Abstract

It has been reported that Vacor, a rodenticide containing N-3-pyridylmethyl-N'-p-nitrophenyl urea, causes insulin-dependent diabetes mellitus. The pathomechanism of Vacor-induced diabetes mellitus has not been clarified yet. The effect of Vacor, therefore, was studied in terms of insulin release from isolated rat pancreatic islets. Vacor suppressed glucose-stimulated insulin release, but did not affect the insulin release induced by theophylline or 12-o-tetra-decanoylphorbol 13-acetate. It is suspected that the suppression of insulin release from pancreatic islets by Vacor may contribute to the pathogenesis of Vacor-induced diabetes mellitus and that this suppression might not be related to cAMP and C-kinase.

PMID:
2663966
DOI:
10.1007/BF03349985
[Indexed for MEDLINE]

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