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Trends Plant Sci. 2015 Dec;20(12):814-821. doi: 10.1016/j.tplants.2015.10.003. Epub 2015 Nov 27.

Paralogue Interference Affects the Dynamics after Gene Duplication.

Author information

1
Department of Biochemical Ecology and Molecular Evolution, Botanical Institute, Christian-Albrechts-University, 24098 Kiel, Germany. Electronic address: ekaltenegger@bot.uni-kiel.de.
2
Department of Biochemical Ecology and Molecular Evolution, Botanical Institute, Christian-Albrechts-University, 24098 Kiel, Germany.

Abstract

Proteins tend to form homomeric complexes of identical subunits, which act as functional units. By definition, the subunits are encoded from a single genetic locus. When such a gene is duplicated, the gene products are suggested initially to cross-interact when coexpressed, thus resulting in the phenomenon of paralogue interference. In this opinion article, we explore how paralogue interference can shape the fate of a duplicated gene. One important outcome is a prolonged time window in which both copies remain under selection increasing the chance to accumulate mutations and to develop new properties. Thereby, paralogue interference can mediate the coevolution of duplicates and here we illustrate the potential of this phenomenon in light of recent new studies.

KEYWORDS:

gene duplication; paralogue interference; protein evolution; selective pressure

PMID:
26638775
DOI:
10.1016/j.tplants.2015.10.003
[Indexed for MEDLINE]

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