Format

Send to

Choose Destination
Biochemistry (Mosc). 2015 Dec;80(12):1629-31. doi: 10.1134/S0006297915120135.

Thymic Involution in Ontogenesis: Role in Aging Program.

Author information

1
Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology, Moscow, 119991, Russia. grgerontol@gmail.com.

Abstract

In most mammals, involution of the thymus occurs with aging. In this issue of Biochemistry (Moscow) devoted to phenoptosis, A. V. Khalyavkin considered involution of a thymus as an example of the program of development and further--of proliferation control and prevention of tumor growth. However, in animals devoid of a thymus (e.g. naked mice), stimulation of carcinogenesis, but not its prevention was observed. In this report, we focus on the involution of the thymus as a manifestation of the aging program (slow phenoptosis). We also consider methods of reversal/arrest of this program at different levels of organization of life (cell, tissue, and organism) including surgical manipulations, hormonal effects, genetic techniques, as well as the use of conventional and mitochondria-targeted antioxidants. We conclude that programmed aging (at least on the model of age-dependent thymic atrophy) can be inhibited.

PMID:
26638690
DOI:
10.1134/S0006297915120135
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Biochemistry (Moscow)
Loading ...
Support Center