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Cell. 2015 Dec 3;163(6):1527-38. doi: 10.1016/j.cell.2015.10.071.

Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish.

Author information

1
Leibniz Institute on Aging-Fritz Lipmann Institute (FLI), Jena 07745, Germany.
2
Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Supérieure de Lyon, CNRS UMR5242, Université Claude Bernard Lyon 1, 69364 Lyon Cedex, France.
3
Genomics Facility, European Brain Research Institute (EBRI) Rita Levi-Montalcini, Rome 00143, Italy.
4
Jena University Hospital, Institute of Human Genetics, Friedrich Schiller University, Jena 07743, Germany.
5
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany; Max Planck Institute for the Physics of Complex Systems, Dresden 01307, Germany.
6
Medical Systems Biology, Ulm University, Ulm 89069, Germany.
7
Medical Systems Biology, Ulm University, Ulm 89069, Germany; International Graduate School in Molecular Medicine at Ulm University (GSC270), Ulm 89069, Germany.
8
Leibniz Institute for Natural Product Research and Infection Biology-Hans-Knoell-Institute (HKI), Jena 07745, Germany.
9
Leibniz Institute on Aging-Fritz Lipmann Institute (FLI), Jena 07745, Germany; Medical Systems Biology, Ulm University, Ulm 89069, Germany; Faculty of Biology and Pharmacy, Friedrich Schiller University Jena, Jena 07743, Germany.
10
Department of Physiological Chemistry, Biocenter, University of Wuerzburg, Wuerzburg 97074, Germany; Comprehensive Cancer Center Mainfranken, University Hospital Wuerzburg, Wuerzburg 97074, Germany.
11
Leibniz Institute on Aging-Fritz Lipmann Institute (FLI), Jena 07745, Germany; Laboratory of Biology, Scuola Normale Superiore, Pisa 56126, Italy.
12
Leibniz Institute on Aging-Fritz Lipmann Institute (FLI), Jena 07745, Germany; Faculty of Biology and Pharmacy, Friedrich Schiller University Jena, Jena 07743, Germany.
13
Leibniz Institute on Aging-Fritz Lipmann Institute (FLI), Jena 07745, Germany. Electronic address: matthias.platzer@leibniz-fli.de.

Abstract

The killifish Nothobranchius furzeri is the shortest-lived vertebrate that can be bred in the laboratory. Its rapid growth, early sexual maturation, fast aging, and arrested embryonic development (diapause) make it an attractive model organism in biomedical research. Here, we report a draft sequence of its genome that allowed us to uncover an intra-species Y chromosome polymorphism representing-in real time-different stages of sex chromosome formation that display features of early mammalian XY evolution "in action." Our data suggest that gdf6Y, encoding a TGF-β family growth factor, is the master sex-determining gene in N. furzeri. Moreover, we observed genomic clustering of aging-related genes, identified genes under positive selection, and revealed significant similarities of gene expression profiles between diapause and aging, particularly for genes controlling cell cycle and translation. The annotated genome sequence is provided as an online resource (http://www.nothobranchius.info/NFINgb).

PMID:
26638077
DOI:
10.1016/j.cell.2015.10.071
[Indexed for MEDLINE]
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