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AIDS. 2016 Feb 20;30(4):667-70. doi: 10.1097/QAD.0000000000000992.

HIV infection and arterial stiffness among older-adults taking antiretroviral therapy in rural Uganda.

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aDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital bMassachusetts General Hospital Center for Global Health cHarvard Medical School dDepartment of Medicine, Brigham and Women's Hospital, Boston, MA, USA eFaculty of Internal Medicine, Mbarara University of Science and Technology, Mbarara, Uganda fDivision of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA gUniversity of California, San Francisco, CA, USA hEpicentre Research Base, Mbarara, Uganda iRagon Institute of MGH, MIT and Harvard, Boston, MA, USA jDepartment of Microbiology, Mbarara University of Science and Technology, Mbarara, Uganda.


HIV infection is associated with arterial stiffness, but no studies have assessed this relationship in sub-Saharan Africa. We enrolled 205 participants over 40 years old in Uganda: 105 on antiretroviral therapy for a median of 7 years, and a random sample of 100 age and sex-matched HIV-uninfected controls from the clinic catchment area. The prevalence of arterial stiffness (ankle brachial index ā€Š>ā€Š1.2) was 33%, 18%, 19% and 2% in HIV+ men, HIV- men, HIV+ women, and HIV- women. In multivariable models adjusted for cardiovascular risk factors, HIV+ individuals had over double the prevalence of arterial stiffness (adjusted prevalence ratio 2.86, 95% confidence interval 1.41-5.79, Pā€Š=ā€Š0.003).

[Available on 2017-02-20]
[Indexed for MEDLINE]
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