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Adv Mater. 2016 Feb 3;28(5):898-904. doi: 10.1002/adma.201505023. Epub 2015 Dec 4.

Hierarchical Plasmonic Nanorods and Upconversion Core-Satellite Nanoassemblies for Multimodal Imaging-Guided Combination Phototherapy.

Author information

1
State Key Lab of Food Science and Technology, International Joint Research Laboratory for Biointerface and Biodetection, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, P. R. China.

Abstract

DNA-driven hierarchical core-satellite nanostructures with plasmonic gold nanorod dimers and upconversion nanoparticles are fabricated. Once the core-satellite structure is activated, combined photothermal therapy and photodynamic therapy are carried out under the guidance of upconversion luminesce, T1 -weighted magnetic resonance, photoacoustics, and computed tomography imaging of tumors in vivo, which exhibit the multifunctional biological applications of the DNA-based self-assemblies.

KEYWORDS:

core-satellite; multimodal imaging; nanorods; phototherapy; self-assembly; upconversion nanoparticles

PMID:
26635317
DOI:
10.1002/adma.201505023
[Indexed for MEDLINE]

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