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J Cell Commun Signal. 2016 Mar;10(1):69-75. doi: 10.1007/s12079-015-0315-5. Epub 2015 Dec 3.

A pathway map of glutamate metabolism.

Author information

1
Institute of Bioinformatics, International Technology Park, Bangalore, 560 066, India.
2
School of Biotechnology, KIIT University, Bhubaneswar, 751 024, India.
3
Manipal University, Madhav Nagar, Manipal, 576104, India.
4
Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam, 690525, India.
5
Kasturba Medical College, Manipal University, Mangalore, 576 104, India.
6
YU-IOB Center for Systems Biology and Molecular Medicine, Yenepoya University, Mangalore, 575 018, India.
7
McKusick-Nathans Institute of Genetic Medicine, Baltimore, MD, 21205, USA.
8
Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
9
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
10
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
11
Institute of Bioinformatics, International Technology Park, Bangalore, 560 066, India. somani@ibioinformatics.org.
12
Institute of Bioinformatics, International Technology Park, Bangalore, 560 066, India. harsha@ibioinformatics.org.
13
School of Biotechnology, KIIT University, Bhubaneswar, 751 024, India. harsha@ibioinformatics.org.
14
YU-IOB Center for Systems Biology and Molecular Medicine, Yenepoya University, Mangalore, 575 018, India. harsha@ibioinformatics.org.

Abstract

Glutamate metabolism plays a vital role in biosynthesis of nucleic acids and proteins. It is also associated with a number of different stress responses. Deficiency of enzymes involved in glutamate metabolism is associated with various disorders including gyrate atrophy, hyperammonemia, hemolytic anemia, γ-hydoxybutyric aciduria and 5-oxoprolinuria. Here, we present a pathway map of glutamate metabolism representing metabolic intermediates in the pathway, 107 regulator molecules, 9 interactors and 3 types of post-translational modifications. This pathway map provides detailed information about enzyme regulation, protein-enzyme interactions, post-translational modifications of enzymes and disorders due to enzyme deficiency. The information included in the map was based on published experimental evidence reported from mammalian systems.

KEYWORDS:

Activators; Feedback regulation; Glutamine and inhibitors

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