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J Matern Fetal Neonatal Med. 2016 Oct;29(20):3374-8. doi: 10.3109/14767058.2015.1127345. Epub 2016 Jan 8.

Elevated placenta growth factor levels in the early second-trimester amniotic fluid are associated with preterm delivery.

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a Department of Obstetrics and Gynecology, College of Medicine , the Catholic University of Korea , Seoul , Korea and.
b Department of Laboratory Medicine , College of Medicine, the Catholic University of Korea , Seoul , Korea.



The purpose of this study was to determine how angiogenesis-related factors correlate with preterm delivery.


A cohort of 382 pregnant women undergoing early second-trimester genetic amniocentesis was enrolled and followed-up until delivery, and the amniotic fluid was collected and stored as a nested case-control study. Cases with preterm delivery (nā€‰=ā€‰31) were compared with matched controls with term delivery (nā€‰=ā€‰62). The amniotic fluid concentrations of placenta growth factor (PlGF), angiogenins, angiopoietin-2, soluble fms-like tyrosine kinase and soluble endoglin were determined using enzyme-linked immunosorbent assays.


Women who delivered preterm had a higher amniotic PlGF concentration compared with the control group (median 12.6 pg/ml versus 6.1 pg/ml; p=0.027). Other angiogenesis-related factors did not show any differences between case and control groups. The odds ratio for preterm delivery based on amniotic fluid PlGF was 1.031 (95% confidence interval: 1.002-1.061; p=0.035). Additionally, when the cases were subdivided into early preterm, late preterm and term groups, PlGF values between the early preterm and term delivery groups were significantly different (median 16.6 pg/ml versus 6.1 pg/ml; Bonferroni-adjusted p=0.018).


Amniotic fluid PlGF levels in the early second trimester of pregnancy are associated with preterm delivery.


Amniotic fluid; angiogenic factors; placenta growth factor; preterm delivery

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