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Anal Chem. 2016 Jan 5;88(1):592-5. doi: 10.1021/acs.analchem.5b03636. Epub 2015 Dec 7.

Bioluminescence Probe for Detecting Hydrogen Sulfide in Vivo.

Author information

1
Laboratory of Anaesthesiology & Critical Care Medicine, Translational Neuroscience Center, West China Hospital, Sichuan University , Chengdu, Sichuan 610041, China.
2
Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Shandong University , Jinan, Shandong 250012, China.

Abstract

Considering that hydrogen sulfide (H2S) is an endogenous signaling molecule involved in numerous biological processes, a method for monitoring H2S as a powerful tool for investigating its complicated functions and mechanisms is urgently demanded. Herein, a bioluminescent turn-on probe was reported based on caged strategy for the detection of H2S in vitro and in vivo. This probe will help us understand the intricate contribution of H2S to a variety of physiological and pathological processes.

PMID:
26634959
DOI:
10.1021/acs.analchem.5b03636
[Indexed for MEDLINE]

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