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Cell Res. 2016 Jan;26(1):3-4. doi: 10.1038/cr.2015.144. Epub 2015 Dec 4.

Cancer immunosurveillance: role of patrolling monocytes.

Author information

1
MRC Centre for Reproductive Health, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK.
2
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, NY 10461, USA.

Abstract

Classical inflammatory monocytes and their derivative macrophages promote tumor metastasis whereas CD8(+) T and NK cells restrict tumor growth. In a recent paper published in Science, Hanna and colleagues demonstrate that another monocyte population, nonclassical patrolling monocytes, is enriched in the microvasculature of tumor-challenged lung and reduces tumor metastasis by recruiting NK cells.

PMID:
26634605
PMCID:
PMC4816132
DOI:
10.1038/cr.2015.144
[Indexed for MEDLINE]
Free PMC Article

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