Format

Send to

Choose Destination
J Physiol Biochem. 2016 Sep;72(3):539-53. doi: 10.1007/s13105-015-0456-2. Epub 2015 Dec 3.

High intake of dietary tyramine does not deteriorate glucose handling and does not cause adverse cardiovascular effects in mice.

Author information

1
Institut des Maladies Métaboliques et Cardiovasculaires, Institut National de la Santé et de la Recherche Médicale (INSERM U1048) and Université Paul Sabatier (I2MC-UPS), 31432, Toulouse, Cedex 4, France. christian.carpene@inserm.fr.
2
Institut des Maladies Métaboliques et Cardiovasculaires, Institut National de la Santé et de la Recherche Médicale (INSERM U1048) and Université Paul Sabatier (I2MC-UPS), 31432, Toulouse, Cedex 4, France.
3
Alimentómica, S.L, Empresa de Base Tecnológica de la Universitat de les Illes Balears, Palma de Mallorca, Spain.

Abstract

Tyramine is naturally occurring in food and induces pressor responses. Low-tyramine diets are recommended for patients treated with MAO inhibitors to avoid the fatal hypertensive crisis sadly known as "cheese effect". Hence, tyramine intake is suspected to have toxicological consequences in humans, while its administration to type 1 diabetic rodents has been reported to improve glucose tolerance. We investigated in mice whether prolonged tyramine ingestion could alter glucose homeostasis, insulin sensitivity, adipose tissue physiology or cardiovascular functions. Tyramine was added at 0.04 or 0.14 % in the drinking water since this was estimated to increase by 10- to 40-fold the spontaneous tyramine intake of control mice fed a standard diet. Ten to 12 weeks of such tyramine supplementation did not influence body weight gain, adiposity or food consumption. Both doses (reaching approx. 300 and 1100 μmol tyramine/kg bw/day) decreased nonfasting blood glucose but did not modify glucose tolerance or fasting levels of glucose, insulin or circulating lipids. Blood pressure was not increased in tyramine-drinking mice, while only the higher tested dose moderately increased heart rate without change in its variability. Markers of cardiac tissue injury or oxidative stress remained unaltered, except an increased hydrogen peroxide production in heart preparations. In isolated adipocytes, tyramine inhibited lipolysis similarly in treated and control groups, as did insulin. The lack of serious adverse cardiovascular effects of prolonged tyramine supplementation in normoglycemic mice together with the somewhat insulin-like effects found on adipose cells should lead to reconsider favourably the risk/benefit ratio of the intake of this dietary amine.

KEYWORDS:

Adipocyte; Fat deposition; Glucose homeostasis; Heart rate variability; Monoamine oxidase

PMID:
26634369
DOI:
10.1007/s13105-015-0456-2
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center