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Iran J Cancer Prev. 2015 Oct;8(5):e4019. doi: 10.17795/ijcp-4019. Epub 2015 Oct 27.

Preventing and Therapeutic Effect of Propolis in Radiotherapy Induced Mucositis of Head and Neck Cancers: A Triple-Blind, Randomized, Placebo-Controlled Trial.

Author information

1
Department of Oral Medicine, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, IR Iran.
2
Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, IR Iran.
3
Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, IR Iran.
4
Department of Veterinary Research and Biotechnology, Razi Vaccine and Serum Research Institute, Mashhad, IR Iran.
5
Department of Oral Medicine, Oral and Maxillofacial Diseases Research Center, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, IR Iran.
6
Department of Community Med and Public Health, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran.

Abstract

BACKGROUND:

Mucositis is one of the acute complications of radiotherapy which can ulcerate oral mucosa and cause severe pain and discomfort which can affect oral normal function. Propolis is a natural source of flavenoid which has antiulcer, antibacterial, antifungal, healing and anti-inflammatory effects. Using such an affordable compound without any bad smell or taste that has reasonable price can help the radiotherapy undergoing patients.

OBJECTIVES:

Our goal is assessing the preventing and therapeutic effect of propolis in radiotherapy induced mucositis in patients with head and neck cancer.

PATIENTS AND METHODS:

In a randomized triple blind clinical trial, 20 patient were selected randomly to swish and swallow 15 ml of water based extract of propolis mouth wash 3 times a day in the case group (n = 10) and 15 ml placebo mouth wash in control group (n = 10). we use NIC-CTC scale for determining mucositis grading.

RESULTS:

We use T-test, Man-Whitney, Chi-square, and Friedman as analyzing tests. Case group had significantly (P < 0.05) lower grade of mucositis in all of the follow-ups, but xerostomia is not significantly different in two groups (P > 0.05).

CONCLUSIONS:

This is a pilot study which shows water based extract of propolis efficiently prevents and heals radiotherapy induced mucositis.

KEYWORDS:

Cancer; Mouthwashes; Mucositis; Propolis; Radiotherapy

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