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Macromol Biosci. 2016 Apr;16(4):522-34. doi: 10.1002/mabi.201500349. Epub 2015 Dec 3.

Zwitterionic Cellulose Carbamate with Regioselective Substitution Pattern: A Coating Material Possessing Antimicrobial Activity.

Author information

1
Center of Excellence for Polysaccharide Research, Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University Jena, Humboldtstraße 10, 07743, Jena, Germany.
2
Materials Science, Otto Schott Institute of Materials Research, Friedrich Schiller University Jena, Löbdergraben 32, 07743, Jena, Germany.
3
Jena Center of Microbial Communication (JCMC), Neugasse 23, 07743, Jena, Germany.
4
Bio Pilot Plant, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Adolf-Reichwein-Straße 23, 07745, Jena, Germany.
5
Institute of Medical Microbiology, Jena University Hospital, Erlanger Allee 101, 07747, Jena, Germany.

Abstract

A polyzwitterion is synthesized by regioselective functionalization of cellulose possessing a uniform charge distribution. The positively charged ammonium group is present at position 6, while the negative charge of carboxylate is located at positions 2 and 3 of the repeating unit. The molecular structure of the biopolymer derivative is proved by NMR spectroscopy. This cellulose-based zwitterion is applied to several support materials by spin-coating and characterized by means of atomic force microscope, contact angle measurements, ellipsometry, and X-ray photoelectron spectroscopy. The coatings possess antimicrobial activity depending on the support materials (glass, titanium, tissue culture poly(styrene)) as revealed by confocal laser scanning microscopy and live/dead staining.

KEYWORDS:

E. coli; antimicrobial; cellulose; coating; zwitterion

PMID:
26632022
DOI:
10.1002/mabi.201500349
[Indexed for MEDLINE]

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