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Biochem Biophys Res Commun. 2016 Jan 8;469(2):189-95. doi: 10.1016/j.bbrc.2015.11.099. Epub 2015 Nov 26.

miR-409-3p suppresses breast cancer cell growth and invasion by targeting Akt1.

Author information

1
Department of Breast Surgery, Qilu Hospital, Shandong University, Jinan 250012, China; Department of Thyroid and Breast Surgery, Hospital Affiliated to Binzhou Medical University, 661 Second Huanghe Street, Binzhou 256603, China.
2
Department of Hematology, Hospital Affiliated to Binzhou Medical University, 661 Second Huanghe Street, Binzhou 256603, China.
3
Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
4
Department of Breast Surgery, Qilu Hospital, Shandong University, Jinan 250012, China. Electronic address: qifengy_sdu1@163.com.

Abstract

Altered levels and functions of microRNAs (miRNAs) are correlated with carcinogenesis. While miR-409-3p has been shown to play important roles in several cancer types, its function in the context of breast cancer (BC) remains unknown. In this study, miR-409-3p was significantly downregulated in BC tissues and cell lines, compared with the corresponding control counterparts. Overexpression of miR-409-3p inhibited BC cell proliferation, migration and invasion in vitro and suppressed tumor growth in vivo. Notably, miR-409-3p induced downregulation of Akt1 protein through binding to its 3' untranslated region (UTR). Conversely, restoring Akt1 expression rescued the suppressive effects of miR-409-3p. Our data collectively indicate that miR-409-3p functions as a tumor suppressor in BC through downregulating Akt1, supporting the targeting of the novel miR-409-3p/Akt1 axis as a potentially effective therapeutic approach for BC.

KEYWORDS:

Akt1; Breast cancer; Invasion; Proliferation; miR-409-3p

PMID:
26631969
DOI:
10.1016/j.bbrc.2015.11.099
[Indexed for MEDLINE]

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